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<article class="">			<h1 class="titleBig">Marcatori neurologici, cladribina riduce indici infiammazione</h1>
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                <time class="published" datetime="2023-10-15T16:17:14+00:00">15 ottobre 23</time>
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			<div class="description"><p>La sclerosi multipla recidivante è una malattia neurologica nella quale le <strong>difese immunitarie</strong> attaccano il sistema nervoso centrale, causando infiammazione e danni alla mielina, il rivestimento protettivo dei nervi. Questo può interferire con la trasmissione degli impulsi nervosi e causare una serie di inconvenienti, come <strong>debolezza muscolare</strong>, problemi di equilibrio, difficoltà nella coordinazione e problemi alla vista (diplopia). Questa malattia ha un andamento altalenante, con periodi di remissione e ricadute, ma oggi può essere trattata con terapie che mirano a <strong>ridurre l'infiammazione</strong> e controllare i sintomi.</p>
<p>&nbsp;</p>
<p>Nuove analisi dello <strong>studio Magnify-Ms</strong> dimostrano che i pazienti con sclerosi multipla recidivante trattati con cladribina presentano una riduzione duratura della catena leggera dei neurofilamenti nel siero. Questo è segno che, in due anni, si è <strong>ridotto il danno neuronale</strong> in tutti i sottogruppi di pazienti sottoposti a risonanza magnetica.</p>
<p>&nbsp;</p>
<p>“Stiamo imparando che i neurofilamenti rientrano, probabilmente, tra i biomarcatori rappresentativi sia dell'attività infiammatoria di malattia sia della neurodegenerazione. Avere una molecola in grado di ridurre i livelli di questi biomarcatori rappresenta un segnale molto forte”, ha affermato <strong>Roberto Bergamaschi</strong>, responsabile del centro di ricerca sulla sclerosi multipla del dipartimento di Neurologia generale della <strong>Fondazione Mondino</strong> di Pavia, a margine del congresso internazionale organizzato a Milano dai comitati per il trattamento e la ricerca sulla sclerosi multipla (Ectrims-Actrims) con il supporto di Aism.</p>
<p>&nbsp;</p>
<p>La capacità di ridurre i livelli dei marcatori della molecola della Merck indica chiaramente una efficacia oggettiva nel trattamento della componente infiammatoria responsabile delle recidive e, presumibilmente, anche una capacità nel prevenire la <strong>neurodegenerazione</strong>.</p>
<p>&nbsp;</p>
<p>leggi anche: <a href="https://www.quotidiano.net/blog/malpelo/sclerosi-multipla-da-evobrutinib-a-cladribina-limpegno-di-merck-in-neurologia-33.5915"><em><strong>due settimane, una volta all'anno</strong></em></a></p>
<p>&nbsp;</p>
<p>Secondo Bergamaschi, i dati presentati al congresso mostrano una tendenza crescente a instaurare un <strong>trattamento precoce</strong> con cladribina al fine di prevenire una progressione sfavorevole della malattia. Tuttavia, sussistono ancora delle limitazioni formali che rendono più complicata la prescrizione nelle fasi iniziali: gli esperti auspicano di poter <strong>superare le limitazioni</strong> al fine di garantire un accesso appropriato a una terapia che migliora la qualità della vita delle persone con sclerosi multipla, e la prognosi della malattia.</p>
<p>&nbsp;</p>
<p>leggi anche: <a href="https://www.quotidiano.net/salute/sclerosi-multipla-la-ricerca-punta-sugli-inibitori-btk/"><em><strong>inibitori della tirosin-chinasi Btk</strong></em></a></p></div></article><div class="row hidden-mobile">
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