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WP_Hook->apply_filters() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:310 0.7145 38075000 9. call_user_func_array() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:286 0.7145 38075488 10. icwp_wpsf_init() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:0 0.7180 38163792 11. require_once('/www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php') /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-wpsf.php:52 0.7237 38904456 12. ICWP_WPSF_Plugin_Controller::GetInstance() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:98 0.7237 38906800 13. ICWP_WPSF_Plugin_Controller->__construct() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:118 0.7327 39017016 14. ICWP_WPSF_Plugin_Controller->doLoadTextDomain() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:133 0.7327 39017016 15. ICWP_WPSF_Plugin_Controller->getTextDomain() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:844 0.7327 39017160 16. ICWP_WPSF_Plugin_Controller->getPluginSpec_Property() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:1348 0.7327 39017160 17. ICWP_WPSF_Plugin_Controller->getPluginControllerOptions() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:954 0.7389 39257664 18. ICWP_WPSF_Plugin_Controller->getIsRebuildOptionsFromFile() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:1374 0.7433 39462264 19. ICWP_WPSF_WpFilesystem->getModifiedTime() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:1080 0.7433 39462408 20. ICWP_WPSF_WpFilesystem->getTime() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/common/icwp-wpfilesystem.php:267 0.7433 39462408 21. ICWP_WPSF_WpFilesystem->exists() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/common/icwp-wpfilesystem.php:285 0.7433 39462408 22. ICWP_WPSF_WpFilesystem->getWpfs() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/common/icwp-wpfilesystem.php:47 0.7433 39462408 23. ICWP_WPSF_WpFilesystem->initFileSystem() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/common/icwp-wpfilesystem.php:473 0.7485 40203576 24. WP_Filesystem() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/common/icwp-wpfilesystem.php:484 Warning: require_once(): Unable to allocate memory for pool. in /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/common/icwp-factory.php on line 13 Call Stack: 0.0001 635664 1. {main}() /www/wordpress/blog.quotidiano.net/index.php:0 0.0001 636232 2. require('/www/wordpress/blog.quotidiano.net/wp-blog-header.php') /www/wordpress/blog.quotidiano.net/index.php:17 0.0025 636952 3. require_once('/www/wordpress/blog.quotidiano.net/wp-load.php') /www/wordpress/blog.quotidiano.net/wp-blog-header.php:13 0.0044 637736 4. require_once('/www/wordpress/blog.quotidiano.net/wp-config.php') /www/wordpress/blog.quotidiano.net/wp-load.php:37 0.0063 640280 5. require_once('/www/wordpress/blog.quotidiano.net/wp-settings.php') /www/wordpress/blog.quotidiano.net/wp-config.php:113 0.6537 36314832 6. do_action() /www/wordpress/blog.quotidiano.net/wp-settings.php:327 0.6537 36315896 7. WP_Hook->do_action() /www/wordpress/blog.quotidiano.net/wp-includes/plugin.php:453 0.6538 36316112 8. WP_Hook->apply_filters() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:310 0.7145 38075000 9. call_user_func_array() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:286 0.7145 38075488 10. icwp_wpsf_init() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:0 0.7180 38163792 11. require_once('/www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php') /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-wpsf.php:52 0.7628 40628704 12. ICWP_WPSF_Shield_Security::GetInstance() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:99 0.7628 40629088 13. ICWP_Wordpress_Simple_Firewall->__construct() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:91 0.7628 40629168 14. ICWP_WPSF_Plugin_Controller->loadAllFeatures() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:27 0.7628 40629328 15. ICWP_WPSF_Plugin_Controller->loadCorePluginFeatureHandler() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:1529 0.7629 40630120 16. ICWP_WPSF_Plugin_Controller->loadFeatureHandler() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:1517 0.7783 42133648 17. ICWP_WPSF_FeatureHandler_Base->__construct() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:1603 0.7783 42133648 18. ICWP_WPSF_FeatureHandler_Base->getModuleMeetRequirements() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:105 0.7783 42133648 19. ICWP_WPSF_FeatureHandler_Base->verifyModuleMeetRequirements() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:142 0.7783 42133728 20. ICWP_WPSF_FeatureHandler_Base->getOptionsVo() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:167 0.7783 42133808 21. ICWP_WPSF_Factory::OptionsVo() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:295 Warning: require_once(): Unable to allocate memory for pool. in /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/common/icwp-foundation.php on line 325 Call Stack: 0.0001 635664 1. {main}() /www/wordpress/blog.quotidiano.net/index.php:0 0.0001 636232 2. require('/www/wordpress/blog.quotidiano.net/wp-blog-header.php') /www/wordpress/blog.quotidiano.net/index.php:17 0.0025 636952 3. require_once('/www/wordpress/blog.quotidiano.net/wp-load.php') /www/wordpress/blog.quotidiano.net/wp-blog-header.php:13 0.0044 637736 4. require_once('/www/wordpress/blog.quotidiano.net/wp-config.php') /www/wordpress/blog.quotidiano.net/wp-load.php:37 0.0063 640280 5. require_once('/www/wordpress/blog.quotidiano.net/wp-settings.php') /www/wordpress/blog.quotidiano.net/wp-config.php:113 0.6537 36314832 6. do_action() /www/wordpress/blog.quotidiano.net/wp-settings.php:327 0.6537 36315896 7. WP_Hook->do_action() /www/wordpress/blog.quotidiano.net/wp-includes/plugin.php:453 0.6538 36316112 8. WP_Hook->apply_filters() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:310 0.7145 38075000 9. call_user_func_array() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:286 0.7145 38075488 10. icwp_wpsf_init() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:0 0.7180 38163792 11. require_once('/www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php') /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-wpsf.php:52 0.7628 40628704 12. ICWP_WPSF_Shield_Security::GetInstance() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:99 0.7628 40629088 13. ICWP_Wordpress_Simple_Firewall->__construct() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:91 0.7628 40629168 14. ICWP_WPSF_Plugin_Controller->loadAllFeatures() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:27 0.7628 40629328 15. ICWP_WPSF_Plugin_Controller->loadCorePluginFeatureHandler() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:1529 0.7629 40630120 16. ICWP_WPSF_Plugin_Controller->loadFeatureHandler() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:1517 0.7783 42133648 17. ICWP_WPSF_FeatureHandler_Base->__construct() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:1603 0.7783 42133648 18. ICWP_WPSF_FeatureHandler_Base->getModuleMeetRequirements() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:105 0.7783 42133648 19. ICWP_WPSF_FeatureHandler_Base->verifyModuleMeetRequirements() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:142 0.7783 42133728 20. ICWP_WPSF_FeatureHandler_Base->getOptionsVo() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:167 0.7839 42437152 21. ICWP_WPSF_FeatureHandler_Base->isPremium() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:298 0.7840 42437152 22. ICWP_WPSF_FeatureHandler_Base->hasValidPremiumLicense() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:1116 0.7840 42437152 23. ICWP_WPSF_FeatureHandler_Base->getPremiumLicenseFilterName() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:151 0.7840 42437312 24. ICWP_WPSF_Plugin_Controller->getUniqueRequestId() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:158 0.7918 42717600 25. ICWP_WPSF_Foundation::loadIpService() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:1478 0.7918 42717744 26. ICWP_WPSF_Foundation::requireCommonLib() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/common/icwp-foundation.php:191 Warning: require_once(): Unable to allocate memory for pool. in /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/common/icwp-foundation.php on line 325 Call Stack: 0.0001 635664 1. {main}() /www/wordpress/blog.quotidiano.net/index.php:0 0.0001 636232 2. require('/www/wordpress/blog.quotidiano.net/wp-blog-header.php') /www/wordpress/blog.quotidiano.net/index.php:17 0.0025 636952 3. require_once('/www/wordpress/blog.quotidiano.net/wp-load.php') /www/wordpress/blog.quotidiano.net/wp-blog-header.php:13 0.0044 637736 4. require_once('/www/wordpress/blog.quotidiano.net/wp-config.php') /www/wordpress/blog.quotidiano.net/wp-load.php:37 0.0063 640280 5. require_once('/www/wordpress/blog.quotidiano.net/wp-settings.php') /www/wordpress/blog.quotidiano.net/wp-config.php:113 0.6537 36314832 6. do_action() /www/wordpress/blog.quotidiano.net/wp-settings.php:327 0.6537 36315896 7. WP_Hook->do_action() /www/wordpress/blog.quotidiano.net/wp-includes/plugin.php:453 0.6538 36316112 8. WP_Hook->apply_filters() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:310 0.7145 38075000 9. call_user_func_array() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:286 0.7145 38075488 10. icwp_wpsf_init() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:0 0.7180 38163792 11. require_once('/www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php') /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-wpsf.php:52 0.7628 40628704 12. ICWP_WPSF_Shield_Security::GetInstance() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:99 0.7628 40629088 13. ICWP_Wordpress_Simple_Firewall->__construct() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:91 0.7628 40629168 14. ICWP_WPSF_Plugin_Controller->loadAllFeatures() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:27 0.8845 45398128 15. ICWP_WPSF_Plugin_Controller->loadFeatureHandler() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:1534 0.8874 45707432 16. ICWP_WPSF_FeatureHandler_Base->__construct() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:1603 0.8931 45820608 17. ICWP_WPSF_FeatureHandler_HackProtect->doPostConstruction() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:122 0.8931 45820608 18. ICWP_WPSF_FeatureHandler_HackProtect->setCustomCronSchedules() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/hack_protect.php:12 0.8957 45820984 19. ICWP_WPSF_Foundation::loadWpCronProcessor() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/hack_protect.php:40 0.8957 45821128 20. ICWP_WPSF_Foundation::requireCommonLib() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/common/icwp-foundation.php:150 Warning: include_once(): Unable to allocate memory for pool. in /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php on line 261 Call Stack: 0.0001 635664 1. {main}() /www/wordpress/blog.quotidiano.net/index.php:0 0.0001 636232 2. require('/www/wordpress/blog.quotidiano.net/wp-blog-header.php') /www/wordpress/blog.quotidiano.net/index.php:17 0.0025 636952 3. require_once('/www/wordpress/blog.quotidiano.net/wp-load.php') /www/wordpress/blog.quotidiano.net/wp-blog-header.php:13 0.0044 637736 4. require_once('/www/wordpress/blog.quotidiano.net/wp-config.php') /www/wordpress/blog.quotidiano.net/wp-load.php:37 0.0063 640280 5. require_once('/www/wordpress/blog.quotidiano.net/wp-settings.php') /www/wordpress/blog.quotidiano.net/wp-config.php:113 0.6537 36314832 6. do_action() /www/wordpress/blog.quotidiano.net/wp-settings.php:327 0.6537 36315896 7. WP_Hook->do_action() /www/wordpress/blog.quotidiano.net/wp-includes/plugin.php:453 0.6538 36316112 8. WP_Hook->apply_filters() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:310 0.7145 38075000 9. call_user_func_array() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:286 0.7145 38075488 10. icwp_wpsf_init() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:0 0.7180 38163792 11. require_once('/www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php') /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-wpsf.php:52 0.7628 40628704 12. ICWP_WPSF_Shield_Security::GetInstance() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:99 0.7628 40629088 13. ICWP_Wordpress_Simple_Firewall->__construct() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:91 0.7628 40629168 14. ICWP_WPSF_Plugin_Controller->loadAllFeatures() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:27 0.9772 48125888 15. do_action() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:1546 0.9773 48127024 16. WP_Hook->do_action() /www/wordpress/blog.quotidiano.net/wp-includes/plugin.php:453 0.9773 48127240 17. WP_Hook->apply_filters() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:310 0.9773 48130216 18. call_user_func_array() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:286 0.9773 48130704 19. ICWP_WPSF_FeatureHandler_Base->onRunProcessors() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:0 0.9818 48130864 20. ICWP_WPSF_FeatureHandler_Base->isReadyToExecute() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:198 0.9818 48130864 21. ICWP_WPSF_FeatureHandler_Base->getProcessor() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:236 0.9819 48130864 22. ICWP_WPSF_FeatureHandler_Sessions->loadFeatureProcessor() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:354 0.9819 48130864 23. ICWP_WPSF_FeatureHandler_Base->loadFeatureProcessor() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/sessions.php:16 Warning: require_once(): Unable to allocate memory for pool. in /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/processors/sessions.php on line 7 Call Stack: 0.0001 635664 1. {main}() /www/wordpress/blog.quotidiano.net/index.php:0 0.0001 636232 2. require('/www/wordpress/blog.quotidiano.net/wp-blog-header.php') /www/wordpress/blog.quotidiano.net/index.php:17 0.0025 636952 3. require_once('/www/wordpress/blog.quotidiano.net/wp-load.php') /www/wordpress/blog.quotidiano.net/wp-blog-header.php:13 0.0044 637736 4. require_once('/www/wordpress/blog.quotidiano.net/wp-config.php') /www/wordpress/blog.quotidiano.net/wp-load.php:37 0.0063 640280 5. require_once('/www/wordpress/blog.quotidiano.net/wp-settings.php') /www/wordpress/blog.quotidiano.net/wp-config.php:113 0.6537 36314832 6. do_action() /www/wordpress/blog.quotidiano.net/wp-settings.php:327 0.6537 36315896 7. WP_Hook->do_action() /www/wordpress/blog.quotidiano.net/wp-includes/plugin.php:453 0.6538 36316112 8. WP_Hook->apply_filters() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:310 0.7145 38075000 9. call_user_func_array() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:286 0.7145 38075488 10. icwp_wpsf_init() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:0 0.7180 38163792 11. require_once('/www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php') /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-wpsf.php:52 0.7628 40628704 12. ICWP_WPSF_Shield_Security::GetInstance() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:99 0.7628 40629088 13. ICWP_Wordpress_Simple_Firewall->__construct() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:91 0.7628 40629168 14. ICWP_WPSF_Plugin_Controller->loadAllFeatures() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:27 0.9772 48125888 15. do_action() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:1546 0.9773 48127024 16. WP_Hook->do_action() /www/wordpress/blog.quotidiano.net/wp-includes/plugin.php:453 0.9773 48127240 17. WP_Hook->apply_filters() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:310 0.9773 48130216 18. call_user_func_array() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:286 0.9773 48130704 19. ICWP_WPSF_FeatureHandler_Base->onRunProcessors() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:0 0.9818 48130864 20. ICWP_WPSF_FeatureHandler_Base->isReadyToExecute() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:198 0.9818 48130864 21. ICWP_WPSF_FeatureHandler_Base->getProcessor() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:236 0.9819 48130864 22. ICWP_WPSF_FeatureHandler_Sessions->loadFeatureProcessor() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:354 0.9819 48130864 23. ICWP_WPSF_FeatureHandler_Base->loadFeatureProcessor() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/sessions.php:16 0.9888 48272632 24. include_once('/www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/processors/sessions.php') /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:261 Warning: require_once(): Unable to allocate memory for pool. in /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/processors/basedb.php on line 7 Call Stack: 0.0001 635664 1. {main}() /www/wordpress/blog.quotidiano.net/index.php:0 0.0001 636232 2. require('/www/wordpress/blog.quotidiano.net/wp-blog-header.php') /www/wordpress/blog.quotidiano.net/index.php:17 0.0025 636952 3. require_once('/www/wordpress/blog.quotidiano.net/wp-load.php') /www/wordpress/blog.quotidiano.net/wp-blog-header.php:13 0.0044 637736 4. require_once('/www/wordpress/blog.quotidiano.net/wp-config.php') /www/wordpress/blog.quotidiano.net/wp-load.php:37 0.0063 640280 5. require_once('/www/wordpress/blog.quotidiano.net/wp-settings.php') /www/wordpress/blog.quotidiano.net/wp-config.php:113 0.6537 36314832 6. do_action() /www/wordpress/blog.quotidiano.net/wp-settings.php:327 0.6537 36315896 7. WP_Hook->do_action() /www/wordpress/blog.quotidiano.net/wp-includes/plugin.php:453 0.6538 36316112 8. WP_Hook->apply_filters() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:310 0.7145 38075000 9. call_user_func_array() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:286 0.7145 38075488 10. icwp_wpsf_init() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:0 0.7180 38163792 11. require_once('/www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php') /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-wpsf.php:52 0.7628 40628704 12. ICWP_WPSF_Shield_Security::GetInstance() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:99 0.7628 40629088 13. ICWP_Wordpress_Simple_Firewall->__construct() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:91 0.7628 40629168 14. ICWP_WPSF_Plugin_Controller->loadAllFeatures() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:27 0.9772 48125888 15. do_action() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:1546 0.9773 48127024 16. WP_Hook->do_action() /www/wordpress/blog.quotidiano.net/wp-includes/plugin.php:453 0.9773 48127240 17. WP_Hook->apply_filters() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:310 0.9773 48130216 18. call_user_func_array() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:286 0.9773 48130704 19. ICWP_WPSF_FeatureHandler_Base->onRunProcessors() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:0 0.9818 48130864 20. ICWP_WPSF_FeatureHandler_Base->isReadyToExecute() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:198 0.9818 48130864 21. ICWP_WPSF_FeatureHandler_Base->getProcessor() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:236 0.9819 48130864 22. ICWP_WPSF_FeatureHandler_Sessions->loadFeatureProcessor() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:354 0.9819 48130864 23. ICWP_WPSF_FeatureHandler_Base->loadFeatureProcessor() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/sessions.php:16 0.9888 48272632 24. include_once('/www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/processors/sessions.php') /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:261 0.9924 48403344 25. require_once('/www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/processors/basedb.php') /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/processors/sessions.php:7 Warning: require_once(): Unable to allocate memory for pool. in /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/processors/base_wpsf.php on line 7 Call Stack: 0.0001 635664 1. {main}() /www/wordpress/blog.quotidiano.net/index.php:0 0.0001 636232 2. require('/www/wordpress/blog.quotidiano.net/wp-blog-header.php') /www/wordpress/blog.quotidiano.net/index.php:17 0.0025 636952 3. require_once('/www/wordpress/blog.quotidiano.net/wp-load.php') /www/wordpress/blog.quotidiano.net/wp-blog-header.php:13 0.0044 637736 4. require_once('/www/wordpress/blog.quotidiano.net/wp-config.php') /www/wordpress/blog.quotidiano.net/wp-load.php:37 0.0063 640280 5. require_once('/www/wordpress/blog.quotidiano.net/wp-settings.php') /www/wordpress/blog.quotidiano.net/wp-config.php:113 0.6537 36314832 6. do_action() /www/wordpress/blog.quotidiano.net/wp-settings.php:327 0.6537 36315896 7. WP_Hook->do_action() /www/wordpress/blog.quotidiano.net/wp-includes/plugin.php:453 0.6538 36316112 8. WP_Hook->apply_filters() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:310 0.7145 38075000 9. call_user_func_array() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:286 0.7145 38075488 10. icwp_wpsf_init() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:0 0.7180 38163792 11. require_once('/www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php') /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-wpsf.php:52 0.7628 40628704 12. ICWP_WPSF_Shield_Security::GetInstance() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:99 0.7628 40629088 13. ICWP_Wordpress_Simple_Firewall->__construct() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:91 0.7628 40629168 14. ICWP_WPSF_Plugin_Controller->loadAllFeatures() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:27 0.9772 48125888 15. do_action() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:1546 0.9773 48127024 16. WP_Hook->do_action() /www/wordpress/blog.quotidiano.net/wp-includes/plugin.php:453 0.9773 48127240 17. WP_Hook->apply_filters() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:310 0.9773 48130216 18. call_user_func_array() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:286 0.9773 48130704 19. ICWP_WPSF_FeatureHandler_Base->onRunProcessors() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:0 0.9818 48130864 20. ICWP_WPSF_FeatureHandler_Base->isReadyToExecute() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:198 0.9818 48130864 21. ICWP_WPSF_FeatureHandler_Base->getProcessor() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:236 0.9819 48130864 22. ICWP_WPSF_FeatureHandler_Sessions->loadFeatureProcessor() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:354 0.9819 48130864 23. ICWP_WPSF_FeatureHandler_Base->loadFeatureProcessor() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/sessions.php:16 0.9888 48272632 24. include_once('/www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/processors/sessions.php') /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:261 0.9924 48403344 25. require_once('/www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/processors/basedb.php') /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/processors/sessions.php:7 0.9951 48521840 26. require_once('/www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/processors/base_wpsf.php') /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/processors/basedb.php:7 Warning: include_once(): Unable to allocate memory for pool. in /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php on line 261 Call Stack: 0.0001 635664 1. {main}() /www/wordpress/blog.quotidiano.net/index.php:0 0.0001 636232 2. require('/www/wordpress/blog.quotidiano.net/wp-blog-header.php') /www/wordpress/blog.quotidiano.net/index.php:17 0.0025 636952 3. require_once('/www/wordpress/blog.quotidiano.net/wp-load.php') /www/wordpress/blog.quotidiano.net/wp-blog-header.php:13 0.0044 637736 4. require_once('/www/wordpress/blog.quotidiano.net/wp-config.php') /www/wordpress/blog.quotidiano.net/wp-load.php:37 0.0063 640280 5. require_once('/www/wordpress/blog.quotidiano.net/wp-settings.php') /www/wordpress/blog.quotidiano.net/wp-config.php:113 0.6537 36314832 6. do_action() /www/wordpress/blog.quotidiano.net/wp-settings.php:327 0.6537 36315896 7. WP_Hook->do_action() /www/wordpress/blog.quotidiano.net/wp-includes/plugin.php:453 0.6538 36316112 8. WP_Hook->apply_filters() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:310 0.7145 38075000 9. call_user_func_array() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:286 0.7145 38075488 10. icwp_wpsf_init() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:0 0.7180 38163792 11. require_once('/www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php') /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-wpsf.php:52 0.7628 40628704 12. ICWP_WPSF_Shield_Security::GetInstance() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:99 0.7628 40629088 13. ICWP_Wordpress_Simple_Firewall->__construct() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:91 0.7628 40629168 14. ICWP_WPSF_Plugin_Controller->loadAllFeatures() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:27 0.9772 48125888 15. do_action() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:1546 0.9773 48127024 16. WP_Hook->do_action() /www/wordpress/blog.quotidiano.net/wp-includes/plugin.php:453 0.9773 48127240 17. WP_Hook->apply_filters() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:310 1.0319 49412288 18. call_user_func_array() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:286 1.0319 49412776 19. ICWP_WPSF_FeatureHandler_Base->onRunProcessors() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:0 1.0325 49415016 20. ICWP_WPSF_FeatureHandler_Base->isReadyToExecute() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:198 1.0325 49415016 21. ICWP_WPSF_FeatureHandler_Base->getProcessor() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:236 1.0325 49415016 22. ICWP_WPSF_FeatureHandler_Base->loadFeatureProcessor() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:354 Warning: require_once(): Unable to allocate memory for pool. in /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/processors/login_protect.php on line 105 Call Stack: 0.0001 635664 1. {main}() /www/wordpress/blog.quotidiano.net/index.php:0 0.0001 636232 2. require('/www/wordpress/blog.quotidiano.net/wp-blog-header.php') /www/wordpress/blog.quotidiano.net/index.php:17 0.0025 636952 3. require_once('/www/wordpress/blog.quotidiano.net/wp-load.php') /www/wordpress/blog.quotidiano.net/wp-blog-header.php:13 0.0044 637736 4. require_once('/www/wordpress/blog.quotidiano.net/wp-config.php') /www/wordpress/blog.quotidiano.net/wp-load.php:37 0.0063 640280 5. require_once('/www/wordpress/blog.quotidiano.net/wp-settings.php') /www/wordpress/blog.quotidiano.net/wp-config.php:113 0.6537 36314832 6. do_action() /www/wordpress/blog.quotidiano.net/wp-settings.php:327 0.6537 36315896 7. WP_Hook->do_action() /www/wordpress/blog.quotidiano.net/wp-includes/plugin.php:453 0.6538 36316112 8. WP_Hook->apply_filters() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:310 0.7145 38075000 9. call_user_func_array() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:286 0.7145 38075488 10. icwp_wpsf_init() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:0 0.7180 38163792 11. require_once('/www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php') /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-wpsf.php:52 0.7628 40628704 12. ICWP_WPSF_Shield_Security::GetInstance() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:99 0.7628 40629088 13. ICWP_Wordpress_Simple_Firewall->__construct() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:91 0.7628 40629168 14. ICWP_WPSF_Plugin_Controller->loadAllFeatures() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:27 0.9772 48125888 15. do_action() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:1546 0.9773 48127024 16. WP_Hook->do_action() /www/wordpress/blog.quotidiano.net/wp-includes/plugin.php:453 0.9773 48127240 17. WP_Hook->apply_filters() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:310 1.1025 50097840 18. call_user_func_array() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:286 1.1025 50098328 19. ICWP_WPSF_FeatureHandler_Base->onRunProcessors() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:0 1.1095 50226136 20. ICWP_WPSF_FeatureHandler_Base->doExecuteProcessor() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:199 1.1095 50226136 21. ICWP_WPSF_Processor_LoginProtect->run() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:242 1.1096 50226216 22. ICWP_WPSF_Processor_LoginProtect->getProcessorGasp() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/processors/login_protect.php:29 Warning: require_once(): Unable to allocate memory for pool. in /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/processors/login_protect.php on line 87 Call Stack: 0.0001 635664 1. {main}() /www/wordpress/blog.quotidiano.net/index.php:0 0.0001 636232 2. require('/www/wordpress/blog.quotidiano.net/wp-blog-header.php') /www/wordpress/blog.quotidiano.net/index.php:17 0.0025 636952 3. require_once('/www/wordpress/blog.quotidiano.net/wp-load.php') /www/wordpress/blog.quotidiano.net/wp-blog-header.php:13 0.0044 637736 4. require_once('/www/wordpress/blog.quotidiano.net/wp-config.php') /www/wordpress/blog.quotidiano.net/wp-load.php:37 0.0063 640280 5. require_once('/www/wordpress/blog.quotidiano.net/wp-settings.php') /www/wordpress/blog.quotidiano.net/wp-config.php:113 0.6537 36314832 6. do_action() /www/wordpress/blog.quotidiano.net/wp-settings.php:327 0.6537 36315896 7. WP_Hook->do_action() /www/wordpress/blog.quotidiano.net/wp-includes/plugin.php:453 0.6538 36316112 8. WP_Hook->apply_filters() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:310 0.7145 38075000 9. call_user_func_array() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:286 0.7145 38075488 10. icwp_wpsf_init() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:0 0.7180 38163792 11. require_once('/www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php') /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-wpsf.php:52 0.7628 40628704 12. ICWP_WPSF_Shield_Security::GetInstance() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:99 0.7628 40629088 13. ICWP_Wordpress_Simple_Firewall->__construct() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:91 0.7628 40629168 14. ICWP_WPSF_Plugin_Controller->loadAllFeatures() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:27 0.9772 48125888 15. do_action() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:1546 0.9773 48127024 16. WP_Hook->do_action() /www/wordpress/blog.quotidiano.net/wp-includes/plugin.php:453 0.9773 48127240 17. WP_Hook->apply_filters() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:310 1.1025 50097840 18. call_user_func_array() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:286 1.1025 50098328 19. ICWP_WPSF_FeatureHandler_Base->onRunProcessors() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:0 1.1095 50226136 20. ICWP_WPSF_FeatureHandler_Base->doExecuteProcessor() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:199 1.1095 50226136 21. ICWP_WPSF_Processor_LoginProtect->run() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:242 1.1128 50395184 22. ICWP_WPSF_Processor_LoginProtect->getProcessorLoginIntent() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/processors/login_protect.php:40 Warning: require_once(): Unable to allocate memory for pool. in /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/processors/hack_protect.php on line 81 Call Stack: 0.0001 635664 1. {main}() /www/wordpress/blog.quotidiano.net/index.php:0 0.0001 636232 2. require('/www/wordpress/blog.quotidiano.net/wp-blog-header.php') /www/wordpress/blog.quotidiano.net/index.php:17 0.0025 636952 3. require_once('/www/wordpress/blog.quotidiano.net/wp-load.php') /www/wordpress/blog.quotidiano.net/wp-blog-header.php:13 0.0044 637736 4. require_once('/www/wordpress/blog.quotidiano.net/wp-config.php') /www/wordpress/blog.quotidiano.net/wp-load.php:37 0.0063 640280 5. require_once('/www/wordpress/blog.quotidiano.net/wp-settings.php') /www/wordpress/blog.quotidiano.net/wp-config.php:113 0.6537 36314832 6. do_action() /www/wordpress/blog.quotidiano.net/wp-settings.php:327 0.6537 36315896 7. WP_Hook->do_action() /www/wordpress/blog.quotidiano.net/wp-includes/plugin.php:453 0.6538 36316112 8. WP_Hook->apply_filters() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:310 0.7145 38075000 9. call_user_func_array() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:286 0.7145 38075488 10. icwp_wpsf_init() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:0 0.7180 38163792 11. require_once('/www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php') /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-wpsf.php:52 0.7628 40628704 12. ICWP_WPSF_Shield_Security::GetInstance() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:99 0.7628 40629088 13. ICWP_Wordpress_Simple_Firewall->__construct() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:91 0.7628 40629168 14. ICWP_WPSF_Plugin_Controller->loadAllFeatures() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/init.php:27 0.9772 48125888 15. do_action() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/icwp-plugin-controller.php:1546 0.9773 48127024 16. WP_Hook->do_action() /www/wordpress/blog.quotidiano.net/wp-includes/plugin.php:453 0.9773 48127240 17. WP_Hook->apply_filters() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:310 1.1307 50874712 18. call_user_func_array() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:286 1.1307 50875200 19. ICWP_WPSF_FeatureHandler_Base->onRunProcessors() /www/wordpress/blog.quotidiano.net/wp-includes/class-wp-hook.php:0 1.1332 51001152 20. ICWP_WPSF_FeatureHandler_Base->doExecuteProcessor() /www/wordpress/blog.quotidiano.net/wp-content/plugins/wp-simple-firewall/src/features/base.php:199 1.1332 51001152 21. 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HOMEPAGE > Cronaca > Anticorpi monoclonali mettono Covid alle corde

Anticorpi monoclonali mettono Covid alle corde

in Cronaca

Evviva gli anticorpi monoclonali neutralizzanti. Nel momento in cui i vaccini arrivano col contagocce e siamo come sempre limitati negli spostamenti potrebbe essere questa la soluzione in grado di imbrigliare la cavalcata del nuovo Coronavirus, quando la sindrome prende una brutta piega.

Lo studio Blaze-1, riporta una nota di Eli Lilly, mostra che la terapia sperimentale con anticorpi neutralizzanti ha permesso di ottenere una netta riduzione del rischio ospedalizzazione ed esito infausto nei pazienti Covid-19, con un abbattimento del 70% degli indicatori nei soggetti trattati con la combinazione bamlanivimab (LY-CoV555) etesevimab (LY-CoV016).

I trial di Fase 3 su un migliaio di pazienti indicano che la somministrazione dei due monoclonali ha dato miglioramenti statisticamente significativi anche sui principali traguardi (endpoint) secondari, riducendo ad esempio la carica virale e accelerando la remissione dei sintomi.

«Questi risultati entusiasmanti replicano i dati positivi di Fase 2 - commenta Daniel Skovronsky, presidente Lilly Research Laboratories – con un'importante evidenza clinica sul ruolo che gli anticorpi neutralizzanti potranno svolgere nella lotta alla pandemia. Per quanto riguarda il profilo di sicurezza, «eventi avversi seri sono stati riportati con una frequenza simile» tra chi ha avuto la terapia e chi ha ricevuto il placebo.

Bamlanivimab è un anticorpo monoclonale ricombinante, neutralizzante IgG1 (Mab) diretto contro la proteina spike della SARS-Cov-2. Un farmaco disegnato per bloccare la carica virale e l'ingresso nelle cellule umane, neutralizzando così il virus, potenzialmente trattando il COVID-19. Bamlanivimab è nato dalla collaborazione tra Lilly e AbCellera.

Anche etesevimab è un anticorpo monoclonale neutralizzante umano, ricombinante, che si rivolge alla proteina spike di superficie SARS-CoV-2, e può bloccare il legame del virus con il recettore ACE2 sulla superficie della cellula ospite.

Eli Lilly continua ad accelerare la produzione su vasta scala di etesevimab in collaborazione con Amgen, al fine di arrivare a distribuire fino a un milione di dosi di etesevimab da abbinare a  bamlanivimab entro il primo semestre di quest'anno (250mila dosi nel primo trimestre 2021).

Alessandro Malpelo

QN Quotidiano Nazionale

salute benessere

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